Miguel Perez-Pinzon, Ph.D., FAHA, Chair, International Stroke Conference 2019 Program Committee, offers overviews and perspective on late breaking science being presented at ISC 2019 in Honolulu.  He is Professor of Neurology/Neuroscience, Director, Cerebral Vascular Disease Research Center, Director, Peritz Scheinberg Cerebral Vascular Laboratory, Vice-Chair for Neurology Basic Science at the Miller School of Medicine, Department of Neurology at the University of Miami, Miami, FL.

copyright American Heart Association

"This is the endovascular thrombectomy outcomes in large-core ELVO CT are strongly associated with perfusion core volume and time. Implications from two large cohorts for future targets. This is all based on the thrombectomy story that we already know, that is a great breakthrough in the field. These were mainly in small infarcts. These trials looking at the potential benefits of thrombectomy with patients with larger strokes. In these trials, they recruited 2153 patients treated with mechanical clot removal. 221 of them had large strokes. Only 35 percent of them had mild disability three months after the stroke, which was considered a good outcome. The rate of good outcomes decreased as the signs of the stroke increased. The investigators found that large strokes had higher rates of death, about 50 percent, and developing brain bleeds, up to 75 percent. So for each 10 cc increase in stroke size, the probability of only mild disability decreased by 27 percent. Evidence for future randomized trials would help confirm if these results warrant expanding the treatment of stroke with larger core of strokes."